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Gpx4 at the crossroads of lipid homeostasis and ferroptosis

and breast enlargement

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In TNBC (triple-negative breast cancer), methylation of KEAP1 by PRMT5 (protein arginine methyltransferase 5) results in decreased levels of NFE2L2 and its downstream target gene HMOX1 (heme oxygenase 1), thereby influencing the sensitivity of the cancer cells to ferroptosis [157]

The increased excretion of lead persisted throughout the entire study, and mercury excretion also generally continued with some fluctuations